PRIMARY ENDOCANNABINOIDS

CANNABICYCLOL (CBL)

Cannabicyclol (CBL), like cannabinol (CBN) and cannabichromene, is a degenerative cannabinoid. It is a non-psychoactive phytocannabinoids that is produced in acidic or irradiated environments.

CBL is a minor cannabinoid that occurs naturally in the cannabis plant but has received little research. The majority of material on cannabinoids focuses on their structure and biosynthesis, with little to no mention of their medicinal advantages.

In the United States, it is not included in the UN Convention on Psychotropic Substances and Controlled Substances Act, making it lawful among other small cannabinoids like CBC and CBN.

CBL was found by Korte and Sieper in 1964. Following their finding, they assumed the chemical they had successfully isolated was THC since it has a similar atom configuration to CBL having a double bond.

The chemical was named THC III.  The cannabinoid was re-isolated and renamed to Cannabicyclol in 1967.

CBL, unlike other cannabinoids, is not made up of cannabigerolic acid (CBGA); instead, it is made up of cannabichromene (CBC). When CBC is exposed to light or irradiation over time, it forms. These and other effects prompted early researchers to question if CBL was a naturally occurring cannabinoid in the cannabis plant.

The working nature of CBL.

CBL has received very little attention. There is very little evidence that it interacts with endocannabinoid receptors or other bodily receptors. It is nearly hard to extract and investigate due to its low concentration in the cannabis plant.

Given its similarities to THC and CBC, it's possible it'll operate on cannabinoid receptors in a similar manner.

The majority of the studies on CBL has been anticipated from cannabinoids.

According to studies, a group of cannabinoids, when combined with CBL, can decrease prostaglandin synthesis. These are hormone-like molecules that can control smooth muscle contractions. Following the study, it was discovered that CBL had the lowest biological activity.

Another research published in 1976 found that giving rabbits 8mg/kg of CBL caused significant convulsions and fatality. The results of this study were murky since the chemical was given to two rabbits but only one of them had the response.